Case Studies

The type of reviews previously undertaken cover a very wide variety of topics for a range of clients. They can be broadly categorised under the following headings:


Individual/Exceptional Funding Request Support

  • Omalizumab for cutaneous mastocytosis
  • Adalimumab for immunotherapy-induced arthritis
  • Tofacitinib for ankylosing spondylitis
  • Certolizumab Pegol for Crohn's disease
  • Second Skin splinting for upper limb in cerebral palsy
  • Real time CGM for congenital hyperinsulinaemia
  • Botulinum toxin for hyperhidrosis in a residual amputated limb
  • Binge eating services for high BMI
  • Temperature-controlled laminar airflow device for severe allergic asthma

Joint Drug Formulary Support – Reviews in response to a new drug request

  • Botulinum toxin for gastroparesis
  • Botulinum toxin for pyloric spasm post-oesophagectomy
  • Botulinum toxin for diffuse oesophageal spasm
  • Melatonin for delayed Sleep-Wake Phase Disorder
  • Melatonin for REM Sleep Behaviour Disorder
  • Alteplase for deep vein thrombosis
  • Ulipristal for first-line emergency contraception
  • Apixaban for mitral valve patients
  • Teriparatide in men

Reviews to inform clinical policy development

  • Effectiveness and cost effectiveness of revisional bariatric surgery
  • Impact of timing of tongue-tie division on breastfeeding outcomes
  • Evidence-based criteria for varicose vein surgery
  • Efficacy of steroid joint injections
  • Efficacy of Alfapump
  • Efficacy of adenoidectomy
  • Efficacy of Exogen

CCG Service Development Support

  • Crisis housing
  • Impact of respiratory HOT clinics on hospital admissions
  • Non-pharmacological interventions for adult ADHD
  • Diabetes – impact of structured education
  • Community respiratory services
  • Barriers to social prescribing
  • Refugee and asylum-seekers services
  • Stillbirth - evidence for reducing levels and appropriateness of investigations
  • Management of viral wheeze in preschool children

Public Health Practice Support

  • Scoping review for the benefits and harms associated with menstrual cups
  • Effectiveness and cost-effectiveness of strategies to address high blood pressure in stroke prevention
  • Effectiveness of training for primary school teachers to support mental health
  • Impact of arts-based interventions in mental health
  • Harm to health of glyphosate
  • Mercury emissions from crematoria
  • Fast food outlets: urban planning, takeaways, improving diet, impact of fast food on public health
  • Mindfulness in prisons (inmates and staff); mindfulness in workplace

Local government support

  • Sheltered housing for older people
  • Impact of physical outdoor activity on social isolation in dementia
  • Extra care housing